Navigate to: Documents\My Games\Binding of Isaac Repentance .

This usually means a mod is outdated or conflicting with another. Remove the folders from your mods directory one by one to find the culprit.

Use a tool like WinRAR or 7-Zip to extract the contents.

In the same Documents\My Games\Binding of Isaac Repentance folder, find a file named . Right-click it and select Open with Notepad . Find the line that says EnableMods=0 . Change the 0 to 1 (so it looks like EnableMods=1 ). Save and close the file. Step 5: Troubleshooting

Ensure the mod you downloaded is specifically for Repentance . Mods made for Afterbirth+ may cause the game to crash.